In lieu of an abstract, here is a brief excerpt of the content:Beyond Ratzinger's Republic:Communio's Postliberal TurnSam Zeno Conedera S.J. and Vincent L. Strand S.J.Is the political future of the West a postliberal one? For the past decade, numerous prominent thinkers in America and Europe have been debating this question. Matters that not long ago were merely of historical interest, such as Pope Gelasius I's understanding of the relation between sacral authority and royal power, Thomas Aquinas's thought on monarchy and (...) Robert Bellarmine's theory of the pope's indirect authority in temporal matters are now increasingly studied for their potential answers to contemporary political questions. This development, which would have been nearly unimaginable just a decade earlier, unsurprisingly has been led by Catholics. We say "unsurprisingly" in view of the long pre-modern tradition of Catholic political thought, as well as the Church's long struggle against liberalism during the nineteenth and early twentieth centuries. Some of the current postliberal writers explicitly connect themselves to both of these aspects by using the term "integralist" to describe their position.1 [End Page 889]This "new integralism" represents a radical departure from the mainstream of Catholic political discourse of the last half century, which has largely sought rapprochement with Western liberalism. A group of writers, led by John Courtney Murray, George Weigel, Michael Novak, and Robert George, have held that the American constitutional order is rooted in the natural law tradition, and therefore is basically friendly to Catholic political thought. The Church's role in American life, they say, is upholding the natural law as a public moral philosophy, while embracing the non-establishment clause of the First Amendment as a matter of principle, in accordance with the teachings of the Second Vatican Council. This "Whig Thomism," which for decades represented the predominant outlook of conservative American Catholics, must now face the challenge of a different sort of Thomism represented by the integralists.2While the engagement between Whig Thomists and integralists has received most of the attention from scholars and journalists alike, another postliberal option has emerged in recent years. Its source is a group of Catholic thinkers associated with the Communio theological movement. Their political vision, which has no single name or label, has a complex and subtle relationship with the thought of earlier Communio writers, most of whom shared the Whig Thomist desire for reconciliation with Western liberalism. [End Page 890] The appearance of a Communio postliberalism therefore represents a significant development within this intellectual tradition. The most important representative of the earlier Communio perspective on political questions is Joseph Ratzinger / Pope Benedict XVI, who has recently been lauded as the "most important Catholic thinker of the twentieth century" on matters at the intersection of theology and politics.3In an article titled "Ratzinger's Republic" that appeared in these pages in 2020, we identified a significant tension in his thought about the Church's contribution to political life.4 Exploring Ratzinger's writings on natural law, we demonstrated that two currents are present. In accord with his fundamental theological commitments about nature and grace and about faith and reason, Ratzinger often questioned the effectiveness of arguments from natural law. He claimed that, since reason is historically conditioned, and therefore in the current order marked by sin, reason needs grace and faith to function properly. Yet, on other occasions, Ratzinger strongly endorsed arguments from natural law, highlighting its role as the foundation of a just democratic political order. We traced this ambivalence about natural law back to a dilemma at the heart of Ratzinger's political thought. On the one hand, in accord with his thinking about the relations of nature and grace and faith and reason, Ratzinger argued that the state needs the Church to supply moral values that the state cannot furnish on its own. On the other hand, he believed it belongs to the very nature of the Church to be separate from the state, and he endorsed nonconfessional, religiously pluralistic states.5 In light of these two commitments, Ratzinger argued that the contribution Christians are to make to the state is to supply moral values that were discerned under the influence of grace and divine revelation but... (shrink)

This study of three central themes in the logic of Alexander of Aphrodisias, the greatest of the ancient Aristotelian commentators, provides insight not only into Aristotle's logical writings but also into the tradition of scholarship which they spawned.

This book stands as a panegyric of the glories and grandeur of Indian philosophy without managing to embody or display those heights of attainment itself. In the few essays that are worthwhile, the author attempts to correct a number of misconceptions about Indian thought: that it is world-denying, that it promotes spiritual pessimism, that it bases its philosophical claims more on intuition than on rational argument, and that it is concerned more with inner than with outer reality. In support of (...) his claims, he sets forth what he believes to be the basic tenets of Indian philosophy, which are: the divine or spiritual nature of the universe, the ultimate moral order of the universe, the transmigration of the soul, the ultimate destiny of man through "the liberation of the soul from bondage to the body," and the implicit trust placed in the testimony of seer-saints "to whom they [truths] are supposed to have been revealed beyond doubt in their direct and immediate experience." In a chapter entitled, "Svapramanatva and Svaprakasatva: An Inconsistency in Kumärila's Philosophy," he presents a fairly informative and well-reasoned argument that the validity of cognitions cannot be verified on the basis of both the inherent quality of the senses which give immediate satisfaction and the quality of external conditions which must await subsequent investigation. Finally, he soundly criticizes R. C. Zaehner's The Comparison of Religions for interpreting and evaluating Hindu religion and philosophy through the spectacles of Catholic Christianity. But his own contention, reiterated again and again throughout the book, that "there is nothing in common between Hindu religion and philosophy," makes no sense. Surely, one thing which distinguishes Indian philosophy from Greek and modern philosophy in the western world is the continual insistence by Indian thinkers that philosophical reflection and rational argumentation are not ends in themselves but merely means to salvation, paths to Enlightenment.--J. B. L. (shrink)

Students of philosophy, East and West, will be benefited greatly by this reprint of Professor Raju's pioneering study of comparative philosophy, which is the outgrowth of a series of lectures presented in Saugor University during 1955. Even for comparative philosophy, man must be the leitmotif, the common denominator for analyzing and interpreting the diversity of philosophical traditions. In his attempt to contribute to the "sense of the basic oneness of humanity, the human solidarity in spite of differences," he interprets the (...) three great philosophical traditions in terms of their respective approaches to the inward and outward aspects of reality. The central meaning or thrust of these traditions is expressed in the titles of the major sections of the book: "Western philosophy and the struggle for the liberation of the outward," "Chinese philosophy and human mindfulness," and "Indian philosophy and explication of inwardness." Western philosophy accomplished primarily a "liberating of the object or outwardness from its entanglement with the subject or inwardness." Chinese philosophy, by trying to build an ethics and philosophy on the emotional rather than the rational nature of man, has struck an even balance between the extremes of inward and outward by establishing clear lines of relatedness between individual men, society, and nature. Indian philosophy has been characterized chiefly by a "reflective inwardness," an overriding concern for the nature of the ätman, the interrelationship between intellect and intuition and the way to ultimate liberation from the round of rebirth and redeath through the immediate, intuitive apprehension of the unity of all things. The final section is dedicated to a general overview of the three major traditions in which the author delineates some of the more obvious and central parallels and distinctions among them. While the book is filled with useful information, novices are sure to be misled and professionals disappointed by the attempts to reduce entire religio-philosophical traditions to a set of neat interpretative labels, such as: Judaism is ethical zeal, Christianity is neighborly love, Buddhism is compassion, Islam is social solidarity, and the Upanishads is divine communion.--J. B. L. (shrink)

This work should be quite useful as a problem guide to phenomenalist and dualist metaphysics. Professor Yolton is concerned that any system be read both from an internal and an external perspective keeping them as separate and distinct as possible. He also cautions that the external perspective should not presuppose another metaphysic for that has often resulted in gross misreadings of earlier authors. In the first section of the book, phenomenalism, he shows how, for example, D. M. Armstrong and G. (...) Warnock have misread Berkeley and attacks G. Warnock and J. Austin's principle which rules out use of a technical irreducible language by philosophers. Solipsism and idealism as well as Berkeley's sensory phenomenalism are treated. In the second section of the book, dualism, Professor Yolton argues that some "transcendent Meaning Principle" is necessary to make the non-sensual side of dualism intelligible, outlines Plato's dualism as against Protagorian monism, indicates what he considers B. Russell's dualism and tries to show that Russell's treatment of one side is partially completed by C. I. Lewis' treatment of what Professor Yolton considers the other side. In the third section on meaning and truth he tries to establish 1) that there is a large measure of intranslatability between philosophical systems; 2) that meaning involves referrent necessarily; 3) that truth is defined by ontological rules; and 4) that correspondence is the basic truth-relation. Brief discussion is given of certain aspects of the works of P. Strawson, B. Russell, J. S. Mill, G. Ryle, W. V. O. Quine, Meinong, and Eric Tom. Slightly over half of this book is comprised of papers, some slightly modified, published from 1949 to 1961.--J. B. L. (shrink)

This is a highly original and readable work by an eminent teacher of philosophy and religion and a very gifted writer who is able to discuss the relationship between Indian and Western scholars without being either doctrinaire or dull. He has determined the exact position of Bengal Vaisnavism in relation to other systems of Indian philosophy, especially Advaita Vedanta, by bringing out important points of agreement and disagreement between it and them. After arguing in the first chapter that metaphysics is (...) logically prior to epistemology, he provides a psychological analysis of knowledge according to the three main spokesmen for Vedänta. Subsequent chapters treat God as the ground of physical and spiritual reality, causation, Krsna and his incarnations, and Bhakti or devotional faith as a means of God-realization. Two other chapters which merit a mention provide a comparative analysis of Bengal Vaisnavism and Kierkegaardian existentialism and of Vaisnavism and Christianity. While Kierkegaard and the Vaisnava spokesmen do differ at many points, they also share a good many ideas in common with respect to their respective understandings of God, the nature of man, and man's relationship to the outer world. This is one of the better books written on Indian Vedanta by a contemporary Indian scholar and appropriate for both specialist and layman who might wish a readable and comprehensive but manageable discussion of one of the major schools of Indian philosophy.--J. B. L. (shrink)

This is the second edition of a very imaginative collection of readings in aesthetics from Plato to the present. In this second edition, seven selections have been deleted and fifteen new selections have been added to greatly enhance its usefulness to beginning students in aesthetics. Additional readings on artistic creation and drama have been provided and a number of illustrations of works by Raphael, Giotto, Matisse, Dürer, Brancusi, Henry Moore, et al. have been included this time to illustrate relevant textual (...) materials. As in the first edition, the author's primary intention is to establish the field of aesthetics as having the same integrity and adventuresomeness as other areas of philosophical inquiry and debate. With this goal in view, he has organized the readings around "certain sets of basic problems that still seem worth debating and attempting to solve." Each section is centered around specific problems and issues in aesthetics, beginning with the broadest question, "What is Art?," and moving on to such issues as the nature of the various art forms, the nature of tragedy, the problem of response to art and, finally, the nature and goal of art criticism. Various readers and teachers in aesthetics no doubt, will find fault with or gaps in his selections of readings. But laying aside such parochial matters as ideology and personal taste, this volume puts in the hands of the student of aesthetics a compendium of essays on the major issues and areas of concern in aesthetics which can easily be supplemented by use of a xerox machine. The editor has included such scholarly aids as a brief introduction to each section, interpretative and cross-referential footnotes and a minimal bibliography.--J. B. L. (shrink)

The scholar who translated The Edicts of Ashoka into English has now set out to present and critically analyze some of "The Great Ideas of Indian Culture." While apparently engaging in a search for the ever-elusive "Perennial Philosophy" by invoking Plato, Aristotle, Kant, Hegel, et al., the author's comparative statements come off as being little more than decorative paraphernalia. He submits too completely to the mystique of the Socratic dialogue in claiming that "the outstanding characteristic of Indian thought is dialogue". (...) We can agree that one does find a type of verbal exchange which might merit the designation of "conversation," but not dialogue. At no place in either the Upanisads or Gïta does the student ever feel the slightest compulsion to question or contradict the words of his guru. Nikam also commits the grave philosophical indiscretion of using Platonic language about "universals" to speak of the Vedäntin "Universal Absolute,". This sort of cross-cultural comparison is extremely misleading in cases where the ideas being compared are similar or identical in appearance but dissimilar in substance. Even so, the book is extremely informative, and, in places, inspiring, in its illumination of the subtler dimensions of Indian thought. Western philosophers and interested lay-students should find this small volume most helpful in gaining a succinct but comprehensive presentation of the "Great Ideas of Indian Culture."--J. B. L. (shrink)

Vaisnavism in Bengal is justifiably renowned for its remarkable elaboration of the philosophy and cult of Divine Love as the essential expression of the nature of the God, Visnu-Krsna. This text, the first of six constituent parts expounding the philosophy of Bengal Vaisnavism, critically analyses the eight traditional bases of knowledge as a means of discovering the nature of Ultimate Reality. The author rejects most of the traditional pramänas as inadequate and false in providing "right cognition" of Ultimate Reality: namely, (...) perception inference, comparison, postulation, quantitative reasoning and tradition. Like both Mïmämsäka and Vedänta, he declares that, in the final analysis, only Sruti or Scripture serves as an infallible source of knowledge. But against the Vedänta of Sankara he rejects the notion that Bhagavat-Krsna, the Creator, Sustainer and Destroyer of the universe, can be fully apprehended through mystical intuition and claims that the non-phenomenal or spiritual nature of God is accessible only through devotional love and personal surrender. The devotional path to God encompasses but transcends both the paths of mystical knowledge and ascetic mortification. The highest aspect of the "power of essential selfhood" is personified in Krsna's eternally youthful consort, Rädhä. It is through the mystical realization of Ultimate Reality as the Divine Duality-in-Union as Rädhä-Krsna, that one experiences absolute Being, Consciousness and Bliss which is Brahman of the Upanisads and Vedänta. Sanskrists and students of Indian religion and philosophy will welcome the publication of this most valuable text which attempts for the first time to present the entire philosophy and theology of Gaudiya Vaisnavism of Bengal in systematic form and comprehensive manner.--J. B. L. (shrink)

The notion underlying Upanishadic and Vedäntin philosophy that Reality is unified, unique, and indivisible and that the world of plurality and multiplicity is unreal, has puzzled both Indian philosophers and students of Indian thought in the West. Many Western students of Vedänta have been misled by the idea that, in relation to the Ultimately Real, the phenomenal world is unreal or illusory. They have tended to read such terms as "unreal," "illusory," and "dreamlike" literally and thus have condemned Vedäntins to (...) the wholly untenable and unthinkable position of believing the empirical world to be absolutely non-existent. This most literate and erudite book explores the ontological status of the world of empirical and rational existence in the Upanishads and Shankara, the 9th century systematizer of Advaita Vedänta. Briefly, the argument of the author is that the phenomenal world is merely the tangible manifestation of primal nescience. Ignorance arises and persists because of man's tendency to superimpose the characteristics of one thing as it is recollected upon another thing as it is perceived. The traits of appearance are superimposed upon Reality, the non-Self upon the Self. The most common example used by Vedäntins is the act of mistakenly identifying the rope as a serpent. Only Brahman is real in an absolute and unqualified sense. Vyävahärika is the "world of names and forms based upon ignorance"; it is "the scene of our common endeavors which exhibits intelligible connections and is full of meaning and purpose" when viewed on its own terms and within its own limits. However, its indeterminable ontological status does not take away from its significance to the seeker after truth and Liberation. Perception, inference, intellection, and meditation all can serve as conductors along the path to salvation, provided they are not employed as ends in themselves. In the end, ratiocination must give way to intuitive insight, knowledge about must be superceded by knowledge of.--J. B. L. (shrink)

Here we go again--yet another testimony of disaffection with the western religious and philosophical tradition by a western philosopher who thinks he has found the answer to mankind's deepest longings and questionings in the "mystic east." He writes a somewhat verbose treatise on the transition from the state of confusion in the realm of language to the state of clarity in the realm of silence. Why is it that those who assert a firm belief in the benefit of remaining silent, (...) by and large, fail to practice what they preach? If he must speak, then he should speak clearly and coherently. Such sentences as this--"America is close to Oriental thought as much because she is a continent as otherwise"--simply will not do! Still despite its occasional verbosity and opacity, the book does contain some useful and intriguing accounts of one westerner's encounter with and training in the disciplines of Zen meditation. The author describes the experience of Zen as the physical and spiritual training of the whole man. He portrays the daily temple routine, the proper position for meditation, steps in the regulation of the breath, reflection upon koans and the frequent interviews with the master. In his own words, "the main direction of this philosophic essay is a movement from abstract intellectualism to the particular and to the real." He provides a brief and somewhat simplistic account of the development of recent philosophical movements and attempts to show how certain western philosophical trends which parallel Zen thought can contribute toward a fuller understanding of Zen philosophy. The recent trend which interests him is the tendency in Dewey, James, and Wittgenstein to speak more about the use of language and less about its meanings. This judgment, too, is simplistic but not entirely indefensible, given his purposes.--J. B. L. (shrink)

Over the past decades, mood enhancement effects of various drugs and neuromodulation technologies have been proclaimed. If one day highly effective methods for significantly altering and elevating one’s mood are available, it is conceivable that the demand for them will be considerable. One urgent concern will then be what role physicians should play in providing such services. The concern can be extended from literature on controversial demands for aesthetic surgery. According to Margaret Little, physicians should be aware that certain aesthetic (...) enhancement requests reflect immoral social norms and ideals. By granting such requests, she argues, doctors render themselves complicit to a collective ‘evil’. In this paper, we wish to question the extent to which physicians, psychiatrists and/or neurosurgeons should play a role as ‘moral gatekeepers’ in dealing with suspect demands and norms underlying potential desires to alter one’s mood or character. We investigate and discuss the nature and limits of physician responsibilities in reference to various hypothetical and intuitively problematic mood enhancement requests. (shrink)

A comparative study of business related values among business students was conducted over the last 10 years in two neighbouring countries. Although Estonia and Finland are culturally related, according to an empirical study of managerial values, including the ethical values of business students, the two countries display significant differences. During the last decade, Estonia has changed from being a country characterised by an authoritarian, centralized, totalitarian state socialism, to a democratic country with a free market economy and different attitudes and (...) values. At the same time Finland has experienced almost a century of capitalism and democracy. It is argued that the differences in values exhibited by these two countries could be explained by using the institutional and historical context. The authors propose a model of value hierarchies in relation to institutionalism. (shrink)

In this paper the authors argue that research ethics committees should not be paternalistic by rejecting research that poses risk to people competent to decide for themselves. However it is important they help to ensure valid consent is sought from potential recruits and protect vulnerable people who cannot look after their own best interests. The authors first describe the tragic deaths of Jesse Gelsinger and Ellen Roche. They then discuss the following claims to support their case: competent individuals are epistemologically (...) and ethically in the best position to say which risks are reasonable for them, so RECs should be no more restrictive than the “normal” constraints on people taking risks with themselves; RECs do not judge individual competence ; individual liberty is mostly limited by what serves the public interest, and RECs do not determine public interest; RECs may have a paternalistic role in preventing exploitation of competent people vulnerable to the use of incentives, and in protecting the interests of incompetent people; however, the moral and political authority of RECs has not been established in this respect. (shrink)

This article tackles the current deficit in the supply of cadaveric organs by addressing the family veto in organ donation. The authors believe that the family veto matters—ethically as well as practically—and that policies that completely disregard the views of the family in this decision are likely to be counterproductive. Instead, this paper proposes to engage directly with the most important reasons why families often object to the removal of the organs of a loved one who has signed up to (...) the donor registry—notably a failure to understand fully and deliberate on the information and a reluctance to deal with this sort of decision at an emotionally distressing time. To accommodate these concerns it is proposed to separate radically the process of information, deliberation and agreement about the harvesting of a potential donor's organs from the event of death and bereavement through a scheme of advance commitment. This paper briefly sets out the proposal and discusses in some detail its design as well as what is believed to be the main advantages compared with the leading alternatives. (shrink)

We analyze the correspondence between a five-dimensional U(1)gauge invariant theory and four-dimensional scalar QED, where the fifth dimension (τ)is an invariant parameter of evolution of the manifestly covariant one-particle sector as well as for the full Fock space. The correspondence is represented by the limit in which the width of the photon mass distribution Δs tends to zero and large τ correlations occur. In the limiting procedure, calculation of a twopoint diagram shows that the PauliVillars regularization is intrinsically related to (...) these longrange correlations. (shrink)

David Hoy’s book is a readable and generally clear introduction to the work of Hans-Georg Gadamer and to the contemporary debate surrounding Gadamer’s contribution to the theory of interpretation. Hoy begins with a chapter on a work familiar to American readers and antithetical to Gadamer—E. D. Hirsch’s Validity in Interpretation. Hirsch is shown to be in some respects a follower of the hermeneutics of Schliermacher and Dilthey in that his defense of authorial intention approximates the "empathy" of nineteenth-century hermeneutics. Hoy (...) makes a careful analysis of the problems involved in Hirsch’s distinction between "meaning"—"the meaning of [an author’s] utterance is the meaning he wills to convey" —and significance—the relation between meaning and some other, extra-textual, element or system. Hoy properly questions the view of language inherent in Hirsch’s contention that verbal meaning is entirely determined by an individual will. He notes that Hirsch neglects meaning determined by the semantics of units of text larger than the sentence. Hoy also argues persuasively that Hirsch’s claim to base his meaning/significance distinction in Frege’s opposition between Sinn and Bedeutung constitutes a misreading of Frege, and shows an ambiguity in Hirsch’s conception of the author, sometimes presented as an historical being with a will and intention and at others as the equivalent of the persona or dramatic speaker of the New Critics. (shrink)

In the context of business, interactions between individuals generate social systems that emerge anywhere within a corporation or in its relations with external agents. These systems influence the behaviors of individuals and, as a result, the collective actions we usually attribute to corporations. Social systems thus make a difference in processes of action that are often morally evaluated by internal and external agents to the firm. Despite this relevance, social systems have not yet been the object of specific attention in (...) the literature on moral agency in business. To fill this gap, I construct a theoretical framework based on Luhmann’s ideas on social systems and morality. In particular, I argue that morality is a phenomenon that occurs in communication, and an agent can engage in morality in three different ways (as a moral factor, an expressive moral agent, or a reflective moral agent) depending on the functions it plays in communicative interactions. Based on this framework, I argue that social systems in business can be considered moral agents of those types. (shrink)

We distinguish two types of cases that have potential to generate quasi-cyclical preferences: self-involving choices where an agent oscillates between first- and third-person perspectives that conflict regarding their life-changing implications, and self-serving choices where frame-based reasoning can be “first-personally rational” yet “third-personally irrational.” We argue that the distinction between these types of cases deserves more attention in Bermúdez's account.

This work is a qualitative study of an organism''s physiological adaptative response to stress. The experimental data were selected from a previous study leading to the conclusion that stress may be considered as a topological retraction within a vital space that must be more precisely defined. The experimental methodology uses rat poisoning by neurotoxins. The control parameter is the intensity of the toxic doses. Measured parameters are the animals'' survival rate and the kinetics of cerebral acetylcholinesterase activity. The results, when (...) expressed as a function of the inverted doses, show a characteristic evolution. The pattern of the curve closely resembles a vortex profile. This analogy is studied more extensively in both the physical and biological domains. These findings help to clarify the concept of biological stress which presents the same vectorial properties as hydrodynamic vorticity. In particular, the dissipation of stress and the dissipation of vorticity seem to obey the same laws. This observation is valid for both diffusion and convection processes. The decompensation phase of stress could be compared with the instability and turbulence in flows.Our approach in this paper is mainly to establish a general and phenomenological description of the stress response fitting experimental observations. (shrink)

The aim of this study is to understand the place of Aristotle’s dialectic in his overall theory of intellectual activity. On the way to this goal, the reader is treated to a novel and exciting interpretation of the nature of dialectic. Evans argues that Aristotelian dialectic is a method for progressing from what is intelligible to some group of discussants to what is intelligible without qualification. Evans goes behind this distinction to discover how dialectic can be, as Aristotle claims, the (...) road to the first principles of all the sciences. (shrink)

Toxoplasma gondii is a highly successful parasite capable of infecting virtually all warm-blooded animals by actively invading nucleated host cells and forming a modified compartment where it replicates within the cytosol. The parasite-containing vacuole provides a safe haven, even in professional phagocytes such as macrophages, which normally destroy foreign microbes. In an effort to eliminate the parasite, the host up-regulates a family of immunity-related p47 GTPases (IRGs), which are recruited to the parasite-containing vacuole, resulting in membrane rupture and digestion of (...) the parasite. To avoid this fate, highly virulent strains of Toxoplasma coat the external surface of their vacuole with a secretory serine/threonine kinase, known as ROP18. At this host-pathogen interface, ROP18 phosphorylates and inactivates IRGs, thereby protecting the parasite from killing. These findings reveal a novel molecular mechanism by which the parasite disarms host innate immunity. (shrink)

Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...) cleaving enzyme . In mice, AbetaPP and SP1 mRNA and their protein products were elevated late in life; Abeta levels declined in old age. In monkeys, SP1, AbetaPP, and BACE1 mRNA declined in old age, while protein products and Abeta levels rose. Proteolytic processing in both species did not match production of Abeta. In primates, AbetaPP and SP1 mRNA levels coordinate, but an inverse relationship exists with corresponding protein products as well as Abeta levels. Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing. These findings are important for selecting appropriate models for AD and other age-related diseases. (shrink)

The ethics review system of research is now well-established, at least in the developed world, although there are many differences in how countries view it and go about managing it. The UK specifically is now seeking to revise its system by speeding up the process of ethics approval but only for some studies. It is proposed that only those studies which pose “no material ethical issues” should be “fast-tracked”. However, it is unclear what this means, who should decide and what (...) should be included in this category. In this paper, we go some way towards answering these questions. While we are certain that the debate is only just beginning, we are equally certain that it will continue to run long after the system has been reformed. To stimulate this conversation and to inform a pilot project of the new system directly, we review two candidates to help give some substance to the notion of “material” ethical issues. Firstly, material could mean a certain type or degree of risk. Second, material could mean how physically invasive the research is. We conclude that there is still much work to be done on making the system of governing health and social care consistent and practicable. (shrink)

Background Empirical studies of surrogate decision-making tend to assume that surrogates should make only a 'substituted judgement'—that is, judge what the patient would want if they were mentally competent. Objectives To explore what people want in a surrogate decision-maker whom they themselves select and to test the assumption that people want their chosen surrogate to make only a substituted judgement. Methods 30 undergraduate students were recruited. They were presented with a hypothetical scenario about their expected loss of mental capacity in (...) the future and asked to answer some questions about their choice of surrogate. These data were analysed qualitatively using thematic content analysis. Results Most respondents talked about choosing someone who was caring and competent in certain ways, giving interesting evidence for their judgements. Surprisingly few highlighted how well they thought their chosen surrogate knew their preferences and would be able to make a substituted judgement. Moreover, few specified that their chosen surrogate had similar attitudes and values to their own and so would make a similar decision to theirs in the circumstances presented. Some respondents also referred to the social role of their chosen surrogate or the social dynamics of their situation which influenced their choices, as well as to ideas of reciprocity and characteristics of honesty and loyalty. Conclusion In the event that they lose mental capacity, many people will not select a surrogate to decide about medical treatments on their behalf solely on the basis that they expect their surrogate to make a substituted judgement. (shrink)

In his 1967 paper 'A Causal Theory of Knowing', Alvin Goldman sketched an account of empirical knowledge in terms of appropriate causal connections between the fact known and the knower's belief in that fact. This early causal account has been much criticized, even by Goldman himself in later years. We argue that the theory is much more defensible than either he or its other critics have recognized, that there are plausible internal and external resources available to it which save it (...) from many objections in the literature (in particular, objections raised by Harman, Pappas and Swain, Klein, Dretske, Goldman, Shope, Ackermann, Morawetz, and Collier). (shrink)

In his 1967 paper 'A Causal Theory of Knowing', Alvin Goldman sketched an account of empirical knowledge in terms of appropriate causal connections between the fact known and the knower's belief in that fact. This early causal account has been much criticized, even by Goldman himself in later years. We argue that the theory is much more defensible than either he or its other critics have recognized, that there are plausible internal and external resources available to it which save it (...) from many objections in the literature (in particular, objections raised by Harman, Pappas and Swain, Klein, Dretske, Goldman, Shope, Ackermann, Morawetz, and Collier). (shrink)

In this paper the need for valid evidence of the cost-effectiveness of treatments that have not been properly evaluated, yet are already available, albeit in short supply, are examined. Such treatments cannot be withdrawn, pending proper evaluation, nor can they be made more widely available until they have been shown to be cost-effective. As a solution to this impasse the argument put forward recently by Toroyan et al is discussed. They say that randomised controlled trials of such resources could be (...) done but only if resources are randomly allocated independently of a research context. Relevant outcome data could then be collected for research, given this opportunity. We agree. We disagree with Toroyan et al on a number of points. First, they claim that no ethical issue relating to equipoise arises. We disagree and this disagreement depends on our showing that equipoise should be maintained in a relationship that they do not consider. Secondly, they say that consent to data collection is always needed. Again we disagree. Thirdly, they claim that the previous two issues are the only possible ethical issues that could arise. We argue, instead, that there is a further conflict of interests that has ethical import. (shrink)

It has become increasingly difficult for individuals to exercise meaningful control over the personal data they disclose to companies or to understand and track the ways in which that data is exchanged and used. These developments have led to an emerging consensus that existing privacy and data protection laws offer individuals insufficient protections against harms stemming from current data practices. However, an effective and ethically justified way forward remains elusive. To inform policy in this area, we propose the Ethical Data (...) Practices framework. The framework outlines six principles relevant to the collection and use of personal data—minimizing harm, fairly distributing benefits and burdens, respecting autonomy, transparency, accountability, and inclusion—and translates these principles into action-guiding practical imperatives for companies that process personal data. In addition to informing policy, the practical imperatives can be voluntarily adopted by companies to promote ethical data practices. (shrink)

These rhetorical texts by Apuleius, second-century Latin writer and author of the famous novel Metamorphoses or Golden Ass, have not been translated into English since 1909. They are some of the very few Latin speeches surviving from their century, and constitute important evidence for Latin and Roman North African social and intellectual culture in the second century AD, a period where there is increasing interest amongst classicists and ancient historians. They are the work of a talented writer who is being (...) increasingly viewed as the major literary artist of his time in Latin. (shrink)

In this paper, we respond to Andrew Avins's recent review of methods whose use he advocates in clinical trials, to make them more ethical. He recommends in particular, “unbalanced randomisation”. However, we argue that, before such a recommendation can be made, it is important to establish why unequal randomisation might offer ethical advantages over equal randomisation, other things being equal. It is important to make a pragmatic distinction between trials of treatments that are already routinely available and trials of restricted (...) treatments. We conclude that unequal randomisation could, indeed, be an ethical compromise between protecting the interests of participants and those of society. (shrink)

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

The study examined the influence of the Pond Report on the teaching of medical ethics in the London medical schools. A questionnaire was given to both medical students and college officers. All medical colleges reported that ethics was included in the curriculum. However, from students' replies, it seems that attendance of optional courses is low and that not all current final year medical students have had any formal teaching in medical ethics. Stronger guidelines are necessary to ensure appropriate ethical training (...) in London medical schools. (shrink)

In the late seventies at the Centre for Computers and Law research was started to find means for supporting lawyers' work with the aid of a computer. The research project was called JURICAS. In 1982 a prototype of a JURICAS system was produced and since 1986 seven advisory packages have been brought out on the market in the Netherlands. These packages consist of two main parts, an author's shell and an advisory program. The user cannot make changes to either the (...) shell or the program.In 1988 the JURICAS author's shell became commercially available. A buyer has to make his own advisory program and fill it with his expertise to produce an advisory package. To facilitate the designing, the typing in and the testing of a package a number of utility programs are included in the author's system. (shrink)